{
  "signal_id": "SIG-2026-006",
  "observed_date": "2026-02-24",
  "category": "Healthspan Measurement",
  "title": "PROSPR THRIVE is developing a healthspan score from harmonized longitudinal data",
  "what_changed": "Stanford-led THRIVE will harmonize existing datasets to generate a PROSPR-IC healthspan score and test its accuracy and intervenability in a one-year lifestyle intervention supported by in-home digital assessment.",
  "why_it_matters": "A validated, intervention-responsive healthspan score could materially change trial design, product claims, reimbursement evidence, and how healthspan is measured outside decades-long studies.",
  "affected_actors": [
    "ARPA-H",
    "Stanford",
    "researchers",
    "digital-health developers",
    "regulators"
  ],
  "decision_implication": "Track the construction, validation, endpoint properties, and public availability of the PROSPR-IC score.",
  "status": "Active R&D",
  "evidence_class": "E5 — official federal award description",
  "impact": 5,
  "immediacy": 3,
  "relevance": 5,
  "novelty": 5,
  "adoption_leverage": 5,
  "priority_score": 92,
  "sources": [
    "https://arpa-h.gov/explore-funding/awards/4171"
  ],
  "public_slug": "/signal/2026-02-24-thrive-healthspan-score/",
  "watch_conditions": [
    "Score definition",
    "validation results",
    "intervention responsiveness",
    "regulatory acceptance."
  ],
  "last_verified": "2026-08-08",
  "version": "1.0"
}